IVRT (Franz Diffusion)

If want to make sure that your IVRT testing is done right the first time, look no further than Tergus. We have the largest bank of IVRT Franz Diffusion cells and have developed specialized testing protocols to meet the needs of clients with challenging APIs. Our expertise in IVRT testing is second to none.

IVRT is an FDA-required test used to support post-approval manufacturing changes to a manufacturing site, equipment, excipient, preservative or drug particle size/crystalline form, in compliance with SUPAC-SS requirements.

During topical drug product development, IVRT is used to profile the performance characteristics of several prototypes, applying Quality by Design principles, avoiding issues down the line and allowing the development team to select an appropriate clinical candidate. IVRT is also used in topical generic drug development as an accepted method of comparison to brand products.