Assessing Penetration into Keratinized Structures
MedPharm offers specialized hard tissue and nail permeation testing to evaluate drug absorption, retention, and diffusion in keratinized structures, such as the nail plate, calloused skin, and hyperkeratotic lesions. These studies provide critical insights for the development of topical and transungual therapies targeting conditions like onychomycosis, psoriasis, and nail dystrophies.
Our validated ex vivo nail and keratinized tissue models help optimize penetration enhancer strategies, formulation selection, and treatment efficacy, ensuring that your drug achieves maximum therapeutic impact.
Evaluating Irritation, Metabolism, and Barrier Integrity
At MedPharm, we utilize Reconstructed Human Epithelium (RHE) models to assess the irritation potential, metabolic activity, and barrier integrity of topical and transdermal formulations. These advanced in vitro models provide highly predictive, reproducible, and regulatory-compliant data, assisting developers in optimizing formulations, minimizing risks in clinical studies, and meeting regulatory safety requirements—all while reducing the reliance on animal testing.
Our scientifically validated RHE models mimic the structural and functional properties of human skin and mucosal tissues, making them essential tools for the evaluation of pharmaceutical, cosmetic, and dermatological products.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Evaluating Drug Penetration Through Biological Membranes
MedPharm’s in vitro Permeation Testing (IVPT) is a gold-standard method for assessing how drugs penetrate the skin, mucosal tissues, and other biological membranes. This process ensures that formulations achieve their intended therapeutic effects. IVPT is essential for various localized delivery systems, including topical, transdermal, ophthalmic, nasal, and mucosal applications, as it provides critical insights into permeation kinetics and bioavailability.
Scalable, GMP-Compliant Production for Market Success
MedPharm offers fully scalable, GMP-certified manufacturing solutions to ensure consistent, high-quality topical and transdermal formulations production. We support pharmaceutical companies from the final stages of drug development to full-scale commercial supply by utilizing advanced production technologies, strict quality control measures, and regulatory-compliant processes.
Whether you require large-scale production, specialized compounding, customized packaging, or dedicated facilities for highly potent and hormone-based products, MedPharm provides a flexible and efficient manufacturing platform tailored to meet your specific product and market needs.
Formulation Development
Innovative, Science-Driven Formulation Strategies for Topical & Transmucosal Drug Products
Comprehensive Formulation Development Services
At MedPharm, we guide clients through every stage of formulation development, from pre-formulation studies to commercial viability. We ensure that products meet regulatory requirements, enhance patient compliance, and optimize therapeutic performance.
At MedPharm, our Formulation Development services provide a rigorous, scientifically driven approach to developing safe, effective, and scalable pharmaceutical formulations. Leveraging Quality by Design (QbD) principles, we integrate API characterization, pre-formulation studies, in silico modeling, and in vitro testing to optimize drug performance and mitigate risk before reaching costly clinical phases.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Measuring Drug Release to Optimize Formulation Performance
At MedPharm, our in vitro release testing (IVRT) services provide critical insights into drug release rates, formulation performance, and batch-to-batch consistency for topical and transdermal drug products. IVRT plays a vital role in regulatory submissions, formulation development, and bioequivalence testing, helping pharmaceutical companies accurately assess and improve drug delivery profiles.
Utilizing GMP-compliant methods, regulatory-aligned protocols, and advanced instrumentation, MedPharm delivers precise, reproducible, and scientifically validated IVRT data to support IND, NDA, and ANDA submissions.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
Since 1999, MedPharm has established a strong reputation for delivering exceptional solutions to our clients. We help them navigate the complexities of topical and transdermal product development, ensuring they take the most effective formulation to the clinic.
