IVPT/Skin Permeation Studies

In vitro permeation testing (IVPT) or skin permeation testing is a critical tool for understanding drug delivery into the various layers of skin and can aid in formulation selection. Tergus is a recognized leader in skin penetration studies with expertise in various in vitro and ex vivo models.

Tergus has a large bank of 120+ vertical Franz diffusion cells to support IVPT studies. We can help you screen and select actives with optimal penetration properties, characterize the skin distribution of active ingredients and quantify which formulation delivers the drug to its target skin layer. We can also compare your optimized formulation to marketed products.

Early Safety Screening

  • Skin Irritation
  • Skin Sensitization
  • Ocular Irritation
  • Phototoxicity

Drug Delivery & Early DMPK

  • Skin Penetration (Distribution & Flux)
  • IVRT
  • Skin Binding
  • Early DMPK
  • PK/PD modeling

Drug Activity/Target Engagement Models

  • Retinoid Activity
  • Anti-Oxidant
  • UV Protection
  • Skin Pigmentation/Lightening
  • Ex Vivo Tissue Culture
  • Reconstructed/3D Human Skin
  • Genetically-Modified Human Skin

Consulting Services

  • Strategy for Topical Formulation Development
  • Claims Support
  • Study Design
  • Target/Asset Assessment